Understanding channel structures that lead to active sites or traverse a protein is important in the study of molecular functions such as ion, ligand, and small molecule transport. ChExVis implements an efficient algorithm for automatic identification of significant channels in a protein. The ChExVis web-server also supports interactive visual exploration of multiple channels together with their geometric and physico-chemical properties thereby enabling the understanding of the basic biology of transport through protein channels.

The transmembrane channels identified by ChExVis in the closed (2VL0) and open (3EAM) structures of pentametric ligand gated ion channel. The physico-chemical and conservation profiles are also shown along with the channels.

For more details, pease visit the web-server home-page here.

References

1. Talha Bin Masood, Sankaran Sandhya, Nagasuma Chandra and Vijay Natarajan.
   ChExVis: a tool for molecular channel extraction and visualization.
   BMC Bioinformatics, 2015, 16:119.